vivit peptide NFAT Inhibitor (VIVIT peptide - beauty-crop-peptide-cleansing-balm Inhibitor of calcineurin-mediated NFAT activation VIVIT Peptide: A Selective Inhibitor Targeting the Calcineurin-NFAT Pathway

tesamorelin-dosage-frequency VIVIT peptide is a highly specific and potent inhibitor that plays a crucial role in research and potential therapeutic applications by targeting the calcineurin-NFAT signaling pathway作者：H Yu·2007·被引用次数：96—VIVIT selectively and potently inhibits calcineurin/NFAT interaction, but does not compromise calcineurin phosphatase activity and non-NFAT- .... This peptide acts by selectively interrupting the interaction between calcineurin and Nuclear Factor of Activated T cells (NFAT), a critical mechanism involved in various cellular processes including immune responses, cell growth, and cardiovascular remodeling. Understanding the molecular intricacies and applications of VIVIT peptide is essential for researchers exploring immune modulation and related disease mechanisms.

The efficacy of VIVIT peptide lies in its ability to bind to calcineurin with high affinity, thereby preventing the dephosphorylation and subsequent activation of NFAT. This targeted approach distinguishes it from other immunosuppressive agents that may have broader effects.作者：H Yu·2006·被引用次数：58—Conclusions—VIVITappears to be a specific and potent inhibitor of NFAT activation and thus of NFAT-mediated proliferation and inflammation. Unlike FK506 or CsA ... Unlike broad-spectrum calcineurin inhibitors such as FK506 or Cyclosporin A (CsA), VIVIT peptide primarily inhibits the calcineurin-NFAT interaction without significantly compromising the phosphatase activity of calcineurin itself or affecting non-NFAT signaling pathways作者：J Aramburu·1999·被引用次数：795—TheVIVIT peptide constitutes a highly selective inhibitor of NFAT, which can now be used for direct identification of. NFAT target genes in these various cell.. This specificity is a key advantage, potentially leading to a more favorable therapeutic profile with fewer off-target side effects.

Mechanisms and Applications of VIVIT Peptide

Research has demonstrated various applications and mechanisms of VIVIT peptide.NFAT inhibitor is a cell-permeable peptidewhich inhibits calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT). For instance, the dNP2-VIVIT Ameliorates Experimental Autoimmune Encephalomyelitis in studies, highlighting its potential in treating autoimmune diseases.Description.Inhibitor of calcineurin-mediated NFAT activation; Alternative Names. VIVIT peptide. The synthetic peptide dNP2-VIVIT has been investigated for its inhibitory effects on NFAT function in the context of these conditions. Furthermore, polypeptide 11R-VIVIT has shown promise in stimulating osteoblastogenesis through inhibition of the calcineurin/NFAT signaling pathway作者：H Yu·2006·被引用次数：58—Conclusions—VIVITappears to be a specific and potent inhibitor of NFAT activation and thus of NFAT-mediated proliferation and inflammation. Unlike FK506 or CsA .... The 11R-VIVIT peptide is a well-studied variant, known for its cell-permeable nature and its specific targeting of the calcineurin-NFAT interactionAffinity-Driven Peptide Selection of an NFAT Inhibitor More ....

Another important application involves its use in cellular research for identifying NFAT target genes. The VIVIT peptide constitutes a highly selective inhibitor of NFAT, allowing researchers to directly probe the downstream effects of NFAT activation in various cell types. The development of cell permeable NFAT inhibitory peptide Sim-2-VIVIT and forms like 11R-VIVIT has facilitated *in vitro* studies by enabling easier cellular uptake.Structure-Based Optimization of a Peptidyl Inhibitor against ... Studies have also shown that VIVIT inhibited the production of NO and the secretion of IL-12 p70, IL-23, and TNF, suggesting a broad role for NFAT in inflammatory gene expression and indicating VIVIT's potential in managing inflammatory processes.

VIVIT Peptide in Cardiovascular and Other Research

The therapeutic potential of VIVIT, a selective peptide inhibitor, has been explored in cardiovascular disorders. Research suggests that VIVIT selectively and potently inhibits calcineurin/NFAT interaction, which is implicated in conditions like cardiac hypertrophy. Scientists have also investigated the delivery of the VIVIT Peptide to Human Glioma Cells to Interfere with Calcineurin-NFAT Signaling, demonstrating its potential utility beyond immunological applications. In these studies, VIVIT was expressed as a fusion protein to facilitate its delivery and study its intracellular effects.

The optimized core of VIVIT peptide, derived from the conserved "PxIxIT" sequence found in the NFAT family, effectively blocks the interaction between calcineurin and NFAT. This mechanism is crucial for understanding how NFAT regulates effector functions, such as those seen in CD4+ T helper cells. Moreover, Expression of peptide VIVIT in mammalian cells effectively blocks the CN–NFAT interaction and its downstream signaling, reinforcing its role as a specific modulator of this pathway. The NFAT Inhibitor-1 (VIVIT peptide) is often cited as a superior agent for inhibiting calcineurin-mediated NFAT activation.

For researchers seeking to use this potent inhibitor, several forms are available. The NFAT Inhibitor (VIVIT peptide), often identified by its CAS Number 249537-73-3, is a commercially available reagent with high purity, typically ≥95% (HPLC).NFAT Inhibitor-1 (VIVIT peptide) is a cell-permeable peptide inhibitor of nuclear factor of activated Tcells (NFAT), it is superior at inhibiting calcineurin- ... The 11R-VIVIT peptide is another frequently utilized variant, known for its cell-permeable properties which enhance its utility in experimental settings.Cell permeable NFAT inhibitory peptide Sim-2-VIVIT ... Different product codes and synonyms exist, such as "NFAT regulatory domain" as an alternative name, underscoring the broad research interest in this moleculeSelective inhibition of calcineurin-NFAT signaling by .... The NFAT Inhibitor is described as a cell-permeable peptide that inhibits calcineurin-mediated NFAT activation, and its molecular weight is approximately 1683.94 Da. The chemical formula for one form is C75H118N20O22S.作者：A Ellert-Miklaszewska·2021·被引用次数：8—We used aVIVIT peptidefor interference in calcineurin binding to NFAT via a conserved PxIxIT motif. VIVIT was expressed as a fusion protein with a green ...

In summary, the VIVIT peptide is a significant research tool and potential therapeutic lead compound. Its precise mechanism of action, selectively interfering with calcineurin-NFAT interaction without broad calcineurin inhibition, offers a unique advantage in studying and modulating pathways involved in immunity, inflammation, cardiovascular disease, and other cellular processes.NFAT Inhibitor | ≥99%(HPLC) | Selleck | その他 阻害剤 Continued research into modified versions like 11R-VIVIT and its delivery methods, such as when VIVIT was expressed as a fusion protein, will further illuminate its therapeutic and scientific potential.